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PURPOSE The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy (CTRT) versus radiotherapy alone (RT) for women with high-risk endometrial cancer (EC). Because The Cancer Genome Atlas …
3 1 Samples' DNA were sequenced using the AmpliSeq Cancer Hotspot Panel V.5, a panel consisting of 2 two primer pools designed to detect somatic cancer hotspot mutations covering 82 genes, including 3 the complete POLE exonuclease domain and TP53.Libraries were prepared using 42-84ng of DNA 4 and each sample labelled with a unique barcode …
This combined approach has been studied, but its efficacy relative to that of chemotherapy alone is not known. Patients with stage III endometrial carcinoma treated with chemoradiotherapy in the ...
PORTEC-3 showed an improvement in "failure-free survival", which is the time from diagnosis to the cancer returning or death from the cancer. It is still an important result given that if the cancer returns it may not be possible to cure it.
The PORTEC-3 trial showed that patients with stage III disease who received chemoradiation therapy followed by four cycles of carboplatin and paclitaxel chemotherapy had better overall and 5-year ...
In March 2018, The Lancet Oncology published the initial results from the PORTEC-3 trial. 1 PORTEC-3 was an open-label, multicenter, phase III randomized trial that compared …
In PORTEC-3, all but one (95.8%) of the HER2-positive ECs were classified as p53abn. Given this strong association, we additionally performed DISH on all p53abn EC with absent or any faint membranous staining to ascertain the HER2 status assignment by IHC was correct. In correspondence to the IHC results, none of these p53abn EC showed …
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ÉVALUATION IN VITRO D'UN NÉBULISEUR À TAMIS VIBRANT, SYNCHRONISÉ SUR LES PHASES INSPIRATOIRE ET EXPIRATOIRE, D'UNE VENTILATION NON-INVASIVE À DEUX NIVEAUX DE PRESSION: ANALYSE DE LA DOSE INHALÉE Caroline BOTTEAU Étudiante Bachelor – Filière Physiothérapie Joana RODRIGUES DA SILVA Étudiante …
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cancer (PORTEC-3): patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial. Lancet Oncol 2019;20(9):1273e1285. [3] Post CCB, de Boer SM, Powell ME, Mileshkin L, Katsaros D, Bessette P, et al. Long-term toxicity and health-related quality of life after adjuvant chemoradiation therapy or radiation
The PORTEC 3 study was supported in the UK by CRUK (C7925/A8659). Participation in the PORTEC-3 trial by ANZGOG and TROG were supported by the NHMRC Project Grant 570894 (2008) and by a Cancer Australia Grant (awarded through the 2011 round of the Priority-driven Collaborative Cancer Research Scheme and funded by Cancer Australia).
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Background: The PORTEC-3 trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy versus pelvic radiotherapy alone for women with high-risk endometrial cancer. We updated the analysis to investigate patterns of recurrence and did a post-hoc survival analysis. Methods: In the multicentre randomised phase 3 PORTEC-3 …
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Methods. In the multicentre randomised phase 3 PORTEC-3 trial, women with high-risk endometrial cancer were eligible if they had International Federation of Gynaecology and Obstetrics (FIGO) 2009 stage I, endomeid grade 3 cancer with deep myometrial invasion or lymphovascular space invasion, or both; stage II or III disease; or stage I–III disease …
Methods: In this multimethod analysis, data from 1801 women participating in the randomised PORTEC-1, PORTEC-2, and PORTEC-3 trials were used for statistical analyses and causal inference. The cohort included 714 patients with intermediate-risk endometrial cancer, 427 patients with high-intermediate risk endometrial cancer, and …
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Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label, multicentre, randomised, phase 3 trial. Lancet Oncol. 2018; 19 : 295-309
The PORTEC-3 trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy (CTRT) versus radiotherapy alone (RT) for women with stage I-III endometrial cancer with high-risk features (HREC). Since the TCGA defined 4 molecular subgroups of EC with strong prognostic value, we investigated outcomes and impact of chemotherapy …
The PORTEC-3 trial was initiated to investigate the benefit of adjuvant chemotherapy during and after radiotherapy (chemoradiotherapy) versus pelvic radiotherapy alone for women with high-risk endometrial cancer. Methods PORTEC-3 was an open-label, international, randomised, phase 3 trial involving 103 centres in six clinical
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FFPE tissue was collected from 423 consenting patients from 5 of the 6 clinical trial groups participating in the PORTEC-3 clinical trial. 7 The design and results of the PORTEC-3 trial have been reported previously 7 and are further described in the Data Supplement. Briefly, this international phase III trial enrolled patients with high-risk ...
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Purpose: The survival results of the PORTEC-3 trial showed a significant improvement in both overall and failure-free survival with chemoradiation therapy versus pelvic radiation therapy alone. The present analysis was performed to compare long-term adverse events (AE) and health-related quality of life (HRQOL). Methods and materials: In the study, …
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Aims: Quality assurance in radiotherapy (QART) is essential to ensure the scientific integrity of a clinical trial. This paper reports the findings of the retrospective QART assessment for all centres that participated in PORTEC-3; a randomised controlled trial that compared pelvic radiotherapy with concurrent chemoradiotherapy to the pelvis followed by …
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